TEST DETAILS

SRD5A2 (V89L Variation) Test

Find out how your DNA can help you avoid Burnout or Gyno

DHT productionGynoAndrogens

What gene we test?

SRD5A2 (V89L variation)

Scientific name

Steroid 5 alpha-reductase 2

What does it do?

Encodes an enzyme that catalyzes the conversion of the male sex hormone testosterone into the more potent hormone, dihydrotestosterone (DHT), which is involved in male sexual development, prostate growth, hair follicle regulation and muscle development (indirectly via androgen receptor activation).

Variants overview

VV - May experience stronger effects from testosterone or anabolic steroids
VL - May experience weaker effects from testosterone or anabolic steroids
LL - May experience significantly weaker effects from testosterone or anabolic steroids

Variant Risk Wheel

Detailed Variant Information

VV Variant

Frequency

~50%

Effect

Individuals produce high levels of dihydrotestosterone.

Simple explanation

The body is highly efficient at converting testosterone into the hormone that produces male traits such as male sexual development and muscle development.

What this means

People with this variant may experience stronger effects from testosterone or anabolic steroids—both beneficial (muscle gain) and adverse (acne, hair loss, prostate issues).

VL Variant

Frequency

~40%

Effect

Individuals produce below average levels of dihydrotestosterone.

Simple explanation

The body is less efficient at converting testosterone into the hormone that produces male traits such as male sexual development and muscle development.

What this means

People with this variant may experience weaker effects from testosterone or anabolic steroids—both beneficial (muscle gain) and adverse (acne, hair loss, prostate issues) than those who are VV, but stronger effects than those who are LL.

LL Variant

Frequency

~10%

Effect

Individuals have significantly less dihydrotestosterone activity compared with those who are VL or VV.

Simple explanation

The body is significantly less efficient at converting testosterone into the hormone that produces male traits such as male sexual development and muscle development.

What this means

People with this variant may experience significantly weaker effects from testosterone or anabolic steroids—both beneficial (muscle gain) and adverse (acne, hair loss, prostate issues).

Included in panels

Starter Panel, Core Panel, Complete Panel