TEST DETAILS

UGT2B17 Excretion Variant Test

Know if your genes put you at higher risk of kidney damage

risk awarenessDHT productiontestosterone metabolization

What gene we test?

UGT2B17

Scientific name

UDP-Glucuronosyltransferase 2B17

What does it do?

The UGT2B17 gene encodes an enzyme called UDP-glucuronosyltransferase 2B17. This enzyme helps the body metabolize and excrete steroid hormones, including testosterone, via urine. Most anabolic steroids are lipophilic, meaning they ‘love’ fat. To help the body remove steroid drugs from the blood UGT2B17 adds a chemical group called glucuronic, which is derived from sugar (glucose) resulting in modified steroids which are more soluble in blood.

Variants overview

del/del - Associated with higher risk of steroid accumulation
ins/del - Associated with regular risk of steroid accumulation

Variant Risk Wheel

Detailed Variant Information

del/del Variant

Frequency

Caucasians (~14%), Asian populations (~80%)

Effect

Individuals excrete very low levels of testosterone-glucuronide, even after taking exogenous testosterone.

Simple explanation

The enzyme involved helping the body metabolize and excrete steroid hormones is either absent or less effective.

What this means

People with this variant may be at higher risk of steroid accumulation and potential kidney damage if using anabolic steroids.

ins/del Variant

Frequency

Caucasians (~86%), Asian populations (~20%)

Effect

Individuals excrete regular levels of testosterone-glucuronide when not taking exogenous testosterone, and higher levels when taking exogenous testosterone.

Simple explanation

The enzyme involved helping the body metabolize and excrete steroid hormones is more likely to be present and effective at normal levels.

What this means

People with this variant may still be at risk of steroid accumulation and potential kidney damage if using anabolic steroids, but to a lower degree than those with the del/del variant.

Included in panels

Starter Panel, Core Panel, Complete Panel